The Patriots and Bills rivalry has been pretty lopsided since Brady took over as the starting QB in 2001. This may not be what Bills fans want to hear, but by allaccounts he's more than capable of getting the job done.
Since 2010, the Patriots have outscored the Bills 344-227 (10 games - Patriotsavg: 34.4 ppg, Bills avg: 22.7 ppg).